|
Steroid-induced osteoporosis (SIOP) is osteoporosis arising due to use of glucocorticoids (steroid hormones) - analogous to Cushing's syndrome and involving mainly the axial skeleton. The synthetic glucocorticoid prescription drug prednisone is a main candidate after prolonged intake. Some professional guidelines recommend prophylactic calcium and vitamin D supplementation in patients who take the equivalent of more than 30 mg hydrocortisone (7.5 mg of prednisolone), especially when this is in excess of three months.〔Cochrane Reviews. ("Calcium and vitamin D for treating osteoporosis caused by the use of steroids" ) 〕 The use of thiazide diuretics, and gonadal hormone replacement has also been recommended, with the use of calcitonin, bisphosphonates, sodium fluoride or anabolic steroids also suggested in refractory cases. Alternate day use may not prevent this complication. Mechanisms of SIOP include:〔(Steroid-induced osteoporosis ) By Susan Ott, MD. Updated January 28, 2009. Retrieved on 26 March 2009〕 * Direct inhibition of osteoblast function * Direct enhancement of bone resorption * Inhibition of gastrointestinal calcium absorption * Increased urine calcium loss * Inhibition of sex steroids ==References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Steroid-induced osteoporosis」の詳細全文を読む スポンサード リンク
|